Interprotomer Antibody Deglycosylation
Describes a novel mechanism for site-specific antibody deglycosylation using engineered glycosidases, with implications for immunogenicity reduction in therapeutic proteins.
Read on Nature CommunicationsDOI: 10.1038/s41467-025-xxxxx
Distinct Gut ENGases on Shared N-Glycans
Characterizes the structural basis for gut bacterial N-glycanase specificity and demonstrates how microbiome diversity shapes therapeutic protein tolerance in vivo.
Read on Nature CommunicationsDOI: 10.1038/s41467-024-xxxxx
Potent Efficacy of an IgG-Specific Endoglycosidase Against IgG-Mediated Pathologies
Demonstrates clinical-stage efficacy of engineered IgG-targeting glycosidases in multiple autoimmune disease models, validated through iterative directed evolution.
Read on CellDOI: 10.1016/j.cell.2024.xxxxx
Integrated High-Throughput Selection for IL-9Rα Engineering
Demonstrates the value of integrated sequential selection cycles for simultaneous optimization of affinity, expression, and thermostability.
Read on FEBS JournalDOI: 10.1111/febs.xxxxx