From challenging proteins to effective molecules.
EvoProt combines structure-guided engineering, computational design, and ultra-high-throughput directed evolution, turning your hardest protein optimization challenges into commercially viable solutions.
Scientific services built around your target.
Protein and Enzyme Optimization
Push beyond natural limits. Simultaneous multi-property optimization across thermostability, solubility, catalytic efficiency, and target specificity. Our iterative engineering cycles deliver molecules that perform under real-world conditions.
Clinical Protein Rescue and Prioritization
Revive stalled candidates. We rescue proteins that have failed early development hurdles, improving stability, activity, and manufacturability without compromising efficacy. From liability mapping to validated rescue variants, we move fast and report transparently.
De Novo Binder and Scaffold Discovery
Build new binding proteins from scratch. Using our ultra-high throughput directed evolution pipeline we can screen hundreds of billions of variants in just a few short screening rounds and further enhancing our sequence space exploration capabilities with computational pre-filtering along with rational design decisions.
Immunogenicity Engineering
Reduce immunogenic risk without losing potency. Structure-informed deimmunization strategies, including deglycosylation, T-cell epitope removal, and scaffold humanization, remain compatible with downstream clinical development requirements.
End-to-end support from early design to late-stage rescue.
Characterise
Deep structural and functional analysis to establish precise engineering coordinates and identify key liabilities.
Design
Rational variant design, computational landscape mapping, identification of key domains.
Evolve
Ultra-high-throughput directed evolution across rapid iterative selection cycles with simultaneous multi-property pressure.
Select
Multi-property simultaneous screening and quantitative hit characterisation.
Deliver
Validated sequences, expression constructs, and a full technical documentation package.